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Current treatment for advanced HCC includes mainly sorafenib and more recently approved regorafenib and nivolumab, as chemotherapy has shown little benefit. However, the modest benefit and the low response rate from systemic treatments suggest an increased need for new strategies.

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Importanța markerilor tumorali AFP Alfa-feto proteina Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and hepatic cancer tumor markers mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and hepatic cancer tumor markers malignanciesand 2 treatment resistance in advanced cancers. The ultimate goal is to identify and validate targets for combination therapy hepatic cancer tumor markers radiation and immunotherapy in preclinical studies, and in parallel conduct studies of biomarkers of response in correlative clinical studies.

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Biopsy and FNAC are invasive procedures, especially in the case of deeply located tumors, and may present severe complications such as infection, bleeding, or inflammation. More importantly, they also carry the risk of seeding tumor cells around the sampling area. Indeed, detached cells can be cleared by interstitial fluids to lymph nodes, or into the veins draining the tissue, thus entering the circulation.

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